Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033854 | 0.84 | LMNA (0.56) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL31340117 | 0.82 | LMNA (0.55) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL30638527 | 0.81 | LMNA (0.53) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL28298127 | 0.80 | LMNA (0.77) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL30950112 | 0.80 | LMNA (0.52) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL31288458 | 0.80 | LMNA (0.52) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL29232790 | 0.80 | LMNA (0.52) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL31171634 | 0.80 | LMNA (0.52) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL30742985 | 0.79 | LMNA (0.48) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL31152185 | 0.79 | LMNA (0.51) | LMNAMAPTTSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-A | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-110709392-A | Isoquinoline as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2020-01-17 | — | — | CN | disclosed |