Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 8/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL2205278 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4ITGB1RENANPEP | |
| Tyrosine SCHEMBL28603345 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4ITGB1RENANPEP | |
| Tyrosine SCHEMBL28209802 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4ITGB1RENANPEP | |
| Dl-Phenylalanine SCHEMBL28971378 | 0.90 | ANPEP (0.43) | SLC7A5RENANPEPRNPEPDNPEP | |
| Tyrosine SCHEMBL28971385 | 0.89 | SLC7A5 (0.41) | SLC7A5ITGA4ITGB1RENNTSR2 | |
| Tyrosine SCHEMBL22290100 | 0.89 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1 | |
| Tyrosine SCHEMBL17728298 | 0.89 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1 | |
| Tyrosine SCHEMBL1675510 | 0.89 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1 | |
| Tyrosine SCHEMBL3100805 | 0.89 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1 | |
| Tyrosine SCHEMBL17728297 | 0.89 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108078958-B | Anti-tumor polypeptide nano-drug and preparation method and application thereof | 国家纳米科学中心 | 2020-02-07 | — | — | CN | disclosed |