Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 8/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | EP300 | Q09472 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28372353 | 0.89 | SIRT5 (1.00) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28371417 | 0.86 | SIRT5 (1.00) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28376708 | 0.83 | SIRT5 (0.84) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28376711 | 0.83 | SIRT5 (0.85) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28377581 | 0.82 | SIRT5 (0.80) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28372236 | 0.79 | SIRT5 (0.75) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28375995 | 0.77 | SIRT5 (1.00) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28376697 | 0.76 | TDP1 (0.81) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28885526 | 0.76 | SIRT5 (0.75) | SIRT5MAPTPOLBNPC1RAB9A | |
| SCHEMBL28376738 | 0.75 | SIRT5 (0.81) | SIRT5MAPTPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106977474-B | Substituted 2-cyano-3-phenyl furan-acrylamide derivative and preparation method and application thereof | 四川大学 | 2020-04-07 | — | — | CN | disclosed |