SCHEMBL28375616

SCHEMBL28375616

O=[N+]([O-])c1cc([N+](=O)[O-])c(Br)c(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.49
CYP3A4 P08684 2/20 0.49
ABCC8 Q09428 1/20 0.43
KCNJ11 Q14654 1/20 0.43
GPR35 Q9HC97 4/20 0.42
TDP1 Q9NUW8 4/20 0.42
HIF1A Q16665 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
HPGD P15428 2/20 0.42
ALOX15 P16050 2/20 0.42
KDM4E B2RXH2 1/20 0.42
TTR P02766 1/20 0.42
CYP1A2 P05177 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.42
ALOX12 P18054 1/20 0.42
MAPK1 P28482 1/20 0.42
RECQL P46063 1/20 0.42
PMP22 Q01453 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15271018 0.89 ALDH1A1 (0.47) ALDH1A1CYP3A4ABCC8KCNJ11TDP1
SCHEMBL28588307 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4ABCC8KCNJ11MEN1
SCHEMBL29623700 0.82 ALDH1A1 (0.58) ALDH1A1CYP3A4ABCC8KCNJ11GPR35
SCHEMBL1943291 0.82 ALDH1A1 (0.58) ALDH1A1CYP3A4ABCC8KCNJ11GPR35
SCHEMBL4914101 0.82 ALDH1A1 (0.58) ALDH1A1CYP3A4ABCC8KCNJ11GPR35
SCHEMBL9559771 0.82 ALDH1A1 (0.43) ALDH1A1CYP3A4ABCC8KCNJ11GPR35
SCHEMBL7882883 0.82 ALDH1A1 (0.58) ALDH1A1CYP3A4ABCC8KCNJ11TDP1
SCHEMBL1505922 0.82 ALDH1A1 (0.41) ALDH1A1CYP3A4TDP1HIF1AHPGD
SCHEMBL11586509 0.82 MEN1 (0.44) ALDH1A1CYP3A4ABCC8KCNJ11GPR35
SCHEMBL11589820 0.81 MEN1 (0.43) ALDH1A1CYP3A4ABCC8KCNJ11GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116283802-A Herbicidal compound containing (R) -2- [4- (6-chloroquinolin-2-yloxy) phenoxy ] propionyl structure, and preparation and application thereof 中国农业大学 2023-06-23 CN claimed
CN-116283802-A Herbicidal compound containing (R) -2- [4- (6-chloroquinolin-2-yloxy) phenoxy ] propionyl structure, and preparation and application thereof 中国农业大学 2023-06-23 CN disclosed
CN-106905104-B Synthesis method of 2-bromo-5-fluorobenzotrifluoride 浙江巍华新材料股份有限公司 2019-12-24 CN disclosed