SCHEMBL28375660

SCHEMBL28375660

Cn1cc(C2=C(Cl)C(=O)N(c3ccccc3)C2=O)c2cc(OCc3ccccc3)ccc21

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.48
MAOB P27338 2/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
POLB P06746 1/20 0.42
HTR6 P50406 1/20 0.41
GSK3B P49841 1/20 0.41
AS3MT Q9HBK9 1/20 0.40
SRD5A2 P31213 1/20 0.40
MAOA P21397 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28374335 0.86 GSK3B (0.48) RAB9APOLBGSK3B
SCHEMBL28369549 0.82 KMT2A (0.50) MEN1KMT2APOLBGSK3B
SCHEMBL28373257 0.80 GSK3B (0.48) GSK3B
SCHEMBL28369857 0.79 CCNT1 (0.56) MEN1KMT2APOLBGSK3B
SCHEMBL7830625 0.77 CCNE2 (0.63) GSK3B
SCHEMBL28369506 0.75 GSK3B (0.47) MEN1KMT2APOLBGSK3B
SCHEMBL2176090 0.75 MEN1 (0.53) MAOBMEN1KMT2ANPC1RAB9A
SCHEMBL28375665 0.74 GSK3B (0.44) MEN1KMT2APOLBGSK3B
SCHEMBL28369252 0.73 GSK3B (0.45) MEN1KMT2APOLBGSK3B
SCHEMBL28369715 0.73 GSK3B (0.45) GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110862396-B Synthesis method of pyrrolo [3,4-c ] carbazole-1, 3(2H, 6H) -diketone compound 浙江工业大学 2021-06-04 CN disclosed
CN-110862396-A Synthesis method of pyrrolo [3,4-c ] carbazole-1, 3(2H,6H) -diketone compound 浙江工业大学 2020-03-06 CN disclosed