SCHEMBL28375665

SCHEMBL28375665

Cc1ccc2c(C3=C(Cl)C(=O)N(c4ccccc4)C3=O)cn(C)c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 5/20 0.44
PRKCA P17252 2/20 0.44
CCNT1 O60563 1/20 0.41
CDK9 P50750 1/20 0.41
MAPT P10636 3/20 0.41
USP2 O75604 2/20 0.41
GAA P10253 2/20 0.41
TSHR P16473 2/20 0.41
KDM4E B2RXH2 1/20 0.41
RAD51 Q06609 1/20 0.40
CDK4 P11802 2/20 0.39
CCND1 P24385 2/20 0.39
CDK2 P24941 2/20 0.39
CCNE2 O96020 1/20 0.39
CCNE1 P24864 1/20 0.39
GSK3A P49840 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
RGS12 O14924 1/20 0.39
GMNN O75496 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28369506 0.89 GSK3B (0.47) GSK3BPRKCACCNT1CDK9MAPT
SCHEMBL28369252 0.87 GSK3B (0.45) GSK3BPRKCACCNT1CDK9MAPT
SCHEMBL28369715 0.87 GSK3B (0.45) GSK3BPRKCACCNT1CDK9RAD51
SCHEMBL28369857 0.86 CCNT1 (0.56) GSK3BPRKCACCNT1CDK9MAPT
SCHEMBL28369549 0.82 KMT2A (0.50) GSK3BPRKCACCNT1CDK9MAPT
SCHEMBL28373257 0.80 GSK3B (0.48) GSK3BPRKCACCNT1CDK9KDM4E
SCHEMBL28374335 0.78 GSK3B (0.48) GSK3BPRKCAMAPTGAAKDM4E
SCHEMBL28375660 0.74 GRM5 (0.48) GSK3BMEN1KMT2APOLB
SCHEMBL28373775 0.74 RAD51 (0.37) GSK3BPRKCACCNT1CDK9MAPT
SCHEMBL17067737 0.72 SCN9A (0.52) GSK3BPRKCAKDM4ECYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110862396-B Synthesis method of pyrrolo [3,4-c ] carbazole-1, 3(2H, 6H) -diketone compound 浙江工业大学 2021-06-04 CN disclosed
CN-110862396-A Synthesis method of pyrrolo [3,4-c ] carbazole-1, 3(2H,6H) -diketone compound 浙江工业大学 2020-03-06 CN disclosed