Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22793399 | 0.80 | NOTUM (0.52) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL13943007 | 0.79 | NOTUM (0.40) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL2837602 | 0.79 | NOTUM (0.46) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL22550382 | 0.78 | NOTUM (0.50) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL20718421 | 0.78 | NOTUM (0.50) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL20718428 | 0.78 | NOTUM (0.50) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL22550481 | 0.77 | NOTUM (0.49) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL22550526 | 0.77 | NOTUM (0.49) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL20718135 | 0.77 | NOTUM (0.49) | CTSKNOTUMWNT3ACHEK1ABL1 | |
| SCHEMBL13943003 | 0.77 | NOTUM (0.40) | CTSKNOTUMWNT3ACHEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |