Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 6/20 | 0.55 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21316308 | 0.89 | TRPC5 (0.60) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL16028537 | 0.83 | TRPC5 (0.63) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL16028393 | 0.83 | TRPC5 (0.66) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL18834872 | 0.83 | TRPC5 (0.65) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL16028784 | 0.82 | TRPC5 (0.64) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL16028539 | 0.81 | TRPC5 (0.58) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL16028290 | 0.81 | TRPC5 (0.60) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL18834134 | 0.81 | TRPC5 (0.58) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL19375414 | 0.81 | TRPC5 (0.62) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL18834128 | 0.80 | TRPC5 (0.64) | TRPC5TRPC4KCNH2TP53TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107082782-B | Substituted xanthines and methods of use thereof | 海德拉生物科学有限责任公司 | 2020-03-20 | — | — | CN | disclosed |