Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL4182132 | 0.95 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL14813276 | 0.92 | LMNA (0.84) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL28058647 | 0.91 | LMNA (0.57) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL9990156 | 0.88 | LMNA (0.78) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL28998934 | 0.88 | LMNA (0.71) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL8840892 | 0.88 | LMNA (0.60) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL30899161 | 0.88 | LMNA (0.71) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL14662536 | 0.87 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL17675382 | 0.87 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL303216 | 0.87 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113030311-B | Liquid phase separation method of isomaltulose alcohol and isomer thereof and application thereof | 中国药科大学 | 2023-07-11 | — | — | CN | disclosed |
| CN-109627848-B | Functional ink and printing method thereof | 郑州鸿盛数码科技股份有限公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-113030311-A | Liquid phase separation method of isomaltitol and isomers thereof and application thereof | 中国药科大学 | 2021-06-25 | — | — | CN | disclosed |
| CN-110960551-A | Novel electrolyte sorbitol chiral resuscitation medicine composition | 刘力 | 2020-04-07 | — | — | CN | disclosed |