Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.69 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | JAK1 | P23458 | 2/20 | 0.61 |
| ▸ | TYK2 | P29597 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779022 | 0.89 | MET (0.62) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL15140533 | 0.88 | MET (0.60) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL24006736 | 0.86 | JAK2 (0.54) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL24006750 | 0.86 | JAK2 (0.54) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL30228047 | 0.85 | JAK2 (0.53) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL15140610 | 0.85 | ALK (0.58) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL3386195 | 0.85 | JAK2 (0.53) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL15273697 | 0.85 | JAK2 (0.53) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL15273623 | 0.85 | JAK2 (0.53) | JAK2METJAK1TYK2JAK3 | |
| SCHEMBL2592205 | 0.85 | ALK (0.58) | JAK2METJAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108264500-B | Substituted 2-aminopyridines and preparation method thereof | 正大天晴药业集团股份有限公司 | 2020-04-21 | — | — | CN | disclosed |