Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 15/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16706532 | 1.00 | CMA1 (0.48) | CMA1MAPK1F2PRSS1ELANE | |
| SCHEMBL23863881 | 1.00 | CMA1 (0.48) | CMA1MAPK1F2PRSS1ELANE | |
| SCHEMBL28394567 | 0.92 | F2 (0.56) | CMA1F2PRSS1ACECTRC | |
| SCHEMBL24447150 | 0.92 | F2 (0.56) | CMA1F2PRSS1ACECTRC | |
| SCHEMBL16706511 | 0.92 | F2 (0.56) | CMA1F2PRSS1ACECTRC | |
| SCHEMBL16703018 | 0.90 | ELANE (0.45) | MAPK1F2ELANEACE | |
| SCHEMBL20859022 | 0.89 | CMA1 (0.58) | CMA1ELANECTRC | |
| SCHEMBL28390853 | 0.89 | CMA1 (0.58) | CMA1ELANECTRC | |
| SCHEMBL18103339 | 0.89 | CMA1 (0.58) | CMA1ELANECTRC | |
| SCHEMBL23863946 | 0.89 | F2 (0.52) | CMA1F2PRSS1ACECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111187202-A | NMDA antagonist prodrugs | 阿斯利康(瑞典)有限公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-105683180-B | NMDA antagonist prodrugs | 阿斯利康(瑞典)有限公司 | 2020-01-21 | — | — | CN | disclosed |