SCHEMBL28389293

SCHEMBL28389293

CCOC(C)OC(=O)Cc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.67
ALDH1A1 P00352 1/20 0.47
MAPK1 P28482 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
PAM P19021 1/20 0.46
KLK7 P49862 6/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
CNR2 P34972 1/20 0.44
NPC1 O15118 1/20 0.43
HPGD P15428 1/20 0.43
RAB9A P51151 1/20 0.43
CYP19A1 P11511 1/20 0.43
POLB P06746 1/20 0.43
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
AKR1B1 P15121 1/20 0.42
FAAH O00519 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL279567 0.88 TSHR (0.53) TSHRALDH1A1MAPK1L3MBTL1KLK7
SCHEMBL28389780 0.84 TSHR (0.59) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL9736825 0.83 TSHR (0.71) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL28392237 0.82 TSHR (0.60) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL29109654 0.81 TSHR (0.59) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL8566647 0.81 TSHR (0.50) TSHRALDH1A1MAPK1L3MBTL1SMN1; SMN2
SCHEMBL873430 0.80 TSHR (1.00) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL11327414 0.80 TSHR (0.67) TSHRALDH1A1MAPK1L3MBTL1PAM
SCHEMBL28062257 0.80 TSHR (0.45) TSHRL3MBTL1SMN1; SMN2CNR2NPC1
SCHEMBL28066985 0.80 TSHR (0.57) TSHRALDH1A1MAPK1L3MBTL1PAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112778442-A Olefin polymerization catalyst solid component, preparation method thereof, olefin polymerization catalyst and application 中国石油化工股份有限公司 2021-05-11 CN claimed
CN-112759683-A Olefin polymerization catalyst and application 中国石油化工股份有限公司 2021-05-07 CN claimed
CN-116135892-B Method for preparing bimodal polyethylene resin for pipe material and bimodal polyethylene resin thereof 中国石油化工股份有限公司 2024-10-15 CN disclosed
CN-111057169-B Catalyst for olefin polymerization and preparation method and application thereof 中国石油化工股份有限公司 2023-02-28 CN disclosed
CN-111057168-B Catalyst for olefin polymerization and preparation method and application thereof 中国石油化工股份有限公司 2022-07-12 CN disclosed
CN-112778442-A Olefin polymerization catalyst solid component, preparation method thereof, olefin polymerization catalyst and application 中国石油化工股份有限公司 2021-05-11 CN disclosed
CN-112759683-A Olefin polymerization catalyst and application 中国石油化工股份有限公司 2021-05-07 CN disclosed
CN-111057168-A Catalyst for olefin polymerization and preparation method and application thereof 中国石油化工股份有限公司 2020-04-24 CN disclosed