SCHEMBL28391968

SCHEMBL28391968

O[Si](c1cc[c]cc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL49883 0.84 ESR1 (0.42) ESR1ESR2NR1H2NR1H3
SCHEMBL28720396 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL231521 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL28287944 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
Fluoride SCHEMBL11421433 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL28580119 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL28590369 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL30499381 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL9581966 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL8078146 0.81 ESR1 (0.40) ESR1ESR2NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110996892-A Cosmetic preparation 株式会社资生堂 2020-04-10 CN disclosed