Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2842406 | 0.89 | GAA (0.56) | TSHRMC4RGAAL3MBTL1MAPT | |
| SCHEMBL2841154 | 0.87 | MC4R (0.49) | TSHRMC4RGAAL3MBTL1MAPT | |
| SCHEMBL2844709 | 0.85 | MC4R (0.66) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2842779 | 0.84 | L3MBTL1 (0.51) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2839988 | 0.84 | MC4R (0.49) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2840401 | 0.84 | MC4R (0.49) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2843841 | 0.84 | MC4R (0.49) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2839986 | 0.84 | MC4R (0.49) | TSHRMC4RGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2838266 | 0.83 | MC4R (0.57) | TSHRMC4RGAAL3MBTL1MAPT | |
| SCHEMBL2842320 | 0.83 | MC4R (0.48) | TSHRMC4RGAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |