Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 2/20 | 0.73 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PMM2 | O15305 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30423726 | 0.85 | MPI (1.00) | MPITRPV1ALOX5TSHRMEN1 | |
| SCHEMBL2438599 | 0.85 | MPI (1.00) | MPITRPV1ALOX5TSHRMEN1 | |
| SCHEMBL4142034 | 0.84 | MPI (0.76) | MPITRPV1ALOX5TSHRALDH1A1 | |
| SCHEMBL30540389 | 0.82 | TSHR (0.73) | MPITRPV1MAPTHPGDCYP1A2 | |
| SCHEMBL28666827 | 0.82 | TSHR (0.73) | MPITRPV1MAPTHPGDCYP1A2 | |
| SCHEMBL28345371 | 0.82 | MPI (0.73) | MPITRPV1ALOX5TSHRALDH1A1 | |
| SCHEMBL11279279 | 0.82 | MPI (0.73) | MPITRPV1ALOX5MAPTHPGD | |
| SCHEMBL28345280 | 0.82 | MPI (0.73) | MPITRPV1ALOX5HPGDTSHR | |
| SCHEMBL29552755 | 0.82 | MPI (0.73) | MPITRPV1ALOX5MAPTHPGD | |
| SCHEMBL9647788 | 0.82 | MPI (0.73) | MPITRPV1ALOX5MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110742892-B | Application of 12H-indazole [2,1-a ] cinnoline-12-ketone compound | 浙江工业大学 | 2022-05-24 | — | — | CN | disclosed |
| CN-110742892-A | Application of 12H-indazole [2,1-a ] cinnoline-12-ketone compound | 浙江工业大学 | 2020-02-04 | — | — | CN | disclosed |