Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23850969 | 0.81 | RXFP1 (0.39) | HPGDMAPTSMN1; SMN2TRPV1TRPA1 | |
| SCHEMBL28700611 | 0.78 | HPGD (0.38) | HPGDMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29016419 | 0.78 | SCN9A (0.43) | HPGDMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL24714799 | 0.77 | HPGD (0.49) | HPGDSCN9ASCN7AKCNH2CFTR | |
| SCHEMBL28352934 | 0.77 | HPGD (0.40) | HPGDMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28441612 | 0.76 | RAB9A (0.43) | HPGDMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30422104 | 0.75 | CFTR (0.39) | TPSAB1TPSD1TPSG1CFTR | |
| SCHEMBL28386256 | 0.74 | TRPV1 (0.42) | HPGDMAPTSMN1; SMN2TRPV1TRPA1 | |
| SCHEMBL28496076 | 0.74 | SMN1; SMN2 (0.43) | HPGDMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29159093 | 0.74 | SMN1; SMN2 (0.35) | HPGDMAPTRAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843856-B | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-115836072-A | Inhibitors of KRAS G12C protein and uses thereof | 上海德琪医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-111164083-B | Novel ALK2 inhibitors and methods for inhibiting BMP signaling | 布里格姆妇女医院股份有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-114980976-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-113637005-A | KRAS inhibitors for cancer treatment | 泰励生物科技（上海）有限公司 | 2021-11-12 | — | — | CN | disclosed |
| CN-112915092-A | Combinations of AKT inhibitor compounds and abiraterone and methods of use | 基因泰克公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-112218859-A | Modulators of proteolysis and related methods of use | 阿尔维纳斯运营股份有限公司 | 2021-01-12 | — | — | CN | disclosed |
| CN-111989321-A | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2020-11-24 | — | — | CN | disclosed |
| CN-111643504-A | Combinations of AKT inhibitor compounds and chemotherapeutic agents and methods of use | 基因泰克公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111164083-A | Novel ALK2 inhibitors and methods for inhibiting BMP signaling | 布里格姆妇女医院股份有限公司 | 2020-05-15 | — | — | CN | disclosed |