SCHEMBL28401249

SCHEMBL28401249

Brc1ccccc1C#CI

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.40
ALDH1A1 P00352 3/20 0.36
MAPK1 P28482 1/20 0.33
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
GAA P10253 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30468202 0.86 FFAR1 (0.47) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL2466535 0.86 FFAR1 (0.47) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL2173149 0.81 FFAR1 (0.41) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL8780975 0.77 FFAR1 (0.42) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL2089353 0.77 ALDH1A1 (0.40) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL3282977 0.77 FFAR1 (0.42) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL12408477 0.77 FFAR1 (0.59) FFAR1ALDH1A1CA1CA2
SCHEMBL1920588 0.75 FFAR1 (0.57) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL29843195 0.75 FFAR1 (0.57) FFAR1ALDH1A1MAPK1CA1CA2
SCHEMBL10595226 0.75 ALDH1A1 (0.41) FFAR1ALDH1A1MAPK1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111233617-A Synthesis method of 1-iodoalkyne compound 荆楚理工学院 2020-06-05 CN disclosed