Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amiloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A known ✓ | P37088 | 12/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | THPO | P40225 | 3/20 | 0.60 |
| ▸ | GMNN | O75496 | 3/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amiloride SCHEMBL28595428 | 0.95 | ALDH1A1 (0.55) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL15517241 | 0.92 | SCNN1A (0.58) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL27562 | 0.92 | SCNN1A (0.58) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL21524891 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL29129215 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL3253482 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL1441814 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL41233 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL17986365 | 0.91 | SCNN1A (0.57) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| Amiloride SCHEMBL1487484 | 0.89 | SCNN1A (0.56) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111278810-A | Therapeutic modulators of the reverse mode of ATP synthase | 迈克尔·大卫·福雷斯特 | 2020-06-12 | — | — | CN | disclosed |