SCHEMBL28404628

SCHEMBL28404628

Clc1cccc(COOCc2cccc(Cl)c2)c1

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.69
IDO1 P14902 2/20 0.69
AGXT P21549 2/20 0.69
PNMT P11086 2/20 0.58
MAOB P27338 4/20 0.56
TAAR1 Q96RJ0 1/20 0.54
HTR3E A5X5Y0 2/20 0.53
HTR3B O95264 2/20 0.53
HTR3A P46098 2/20 0.53
HTR3D Q70Z44 2/20 0.53
HTR3C Q8WXA8 2/20 0.53
SIGMAR1 Q99720 1/20 0.52
RXRA P19793 1/20 0.50
RXRB P28702 1/20 0.50
RXRG P48443 1/20 0.50
ENPP2 Q13822 1/20 0.50
HCAR2 Q8TDS4 1/20 0.50
NR4A2 P43354 1/20 0.49
MAOA P21397 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10296002 0.87 CYP3A4 (0.60) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL10866481 0.86 CYP3A4 (0.69) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL1855225 0.84 CYP3A4 (0.67) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL423396 0.83 CYP3A4 (0.60) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL403680 0.82 IDO1 (1.00) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL7040986 0.82 CYP3A4 (0.64) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL13278842 0.82 CYP3A4 (0.64) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL1145772 0.82 CYP3A4 (0.64) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL791970 0.82 CYP3A4 (0.64) CYP3A4IDO1AGXTPNMTMAOB
SCHEMBL4950985 0.82 CYP3A4 (0.64) CYP3A4IDO1AGXTPNMTMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111094287-A Substituted imidazoquinolines 生物技术公司 2020-05-01 CN disclosed