Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416260 | 0.88 | KCNN4 (0.47) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Hydrochloric Acid SCHEMBL28904470 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Fluoride SCHEMBL28904468 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Fluoride SCHEMBL28904466 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| SCHEMBL30581193 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Fluoride SCHEMBL8188285 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Hydrochloric Acid SCHEMBL28904471 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Bromide SCHEMBL102597 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Iodide SCHEMBL114296 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 | |
| Hydrochloric Acid SCHEMBL113885 | 0.85 | KCNN4 (0.45) | TSHRKCNN4ALDH1A1CYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240254117-A1 | PYRIMIDO-HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2024-08-01 | — | — | US | disclosed |
| CN-111039941-B | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109485595-B | Hydrophilic group substituted indole formamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-111039941-A | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2020-04-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240254117-A1 | PYRIMIDO-HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF | TYMS, TYMP, SLC5A11 | TSHR 2811/4885KCNN4 4329/4885ALDH1A1 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.