Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL29018259 | 0.82 | FFAR3 (0.53) | SMN1; SMN2KMT2AMCL1MEN1NPSR1 | |
| Glycine SCHEMBL16714042 | 0.79 | CYP3A4 (0.48) | GLRA1SLC6A9OR51E2KMT2AMEN1 | |
| Acetic Acid SCHEMBL28703177 | 0.78 | FFAR3 (0.44) | SMN1; SMN2KMT2AMCL1MEN1CYP1A2 | |
| Propionic Acid SCHEMBL11359484 | 0.76 | FFAR3 (0.40) | SMN1; SMN2KMT2AMCL1MEN1CYP1A2 | |
| Malonic Acid SCHEMBL21957746 | 0.76 | TDP1 (0.38) | SMN1; SMN2KMT2AMCL1MEN1CYP3A4 | |
| Ethylenediamine SCHEMBL18725865 | 0.75 | TAAR1 (0.42) | CYP1A2TSHRALDH1A1GLATDP1 | |
| Toluene SCHEMBL3905736 | 0.75 | LMNA (0.55) | GLRA1SLC6A9OR51E2SMN1; SMN2KMT2A | |
| SCHEMBL1257818 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AMEN1NPSR1CYP1A2 | |
| Chloroacetic Acid SCHEMBL21957779 | 0.74 | TSHR (0.39) | SMN1; SMN2KMT2AMCL1MEN1CYP3A4 | |
| Bicarbonate SCHEMBL8746323 | 0.73 | TDP1 (0.43) | KMT2AMCL1MEN1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116521-B | Solanesol modified taxol prodrug and preparation method and application thereof | 河南大学 | 2021-11-26 | — | — | CN | disclosed |
| CN-111116521-A | Solanesol modified taxol prodrug and preparation method and application thereof | 河南大学 | 2020-05-08 | — | — | CN | disclosed |