Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405615 | 0.87 | IRAK4 (0.41) | IRAK4 | |
| SCHEMBL28407980 | 0.81 | MAPT (0.37) | IRAK4MAPTCYP3A4BLMPMP22 | |
| SCHEMBL19030014 | 0.80 | IRAK4 (0.48) | IRAK4MAPTLMNAGAA | |
| SCHEMBL20594509 | 0.78 | MAPT (0.52) | IRAK4MAPTCYP3A4BLMPMP22 | |
| SCHEMBL19030707 | 0.77 | IRAK4 (0.48) | IRAK4MAPTLMNAGAA | |
| SCHEMBL19030797 | 0.77 | IRAK4 (0.51) | IRAK4MAPTCYP3A4LMNAGAA | |
| SCHEMBL20594523 | 0.77 | DRD2 (0.47) | IRAK4LMNAGAA | |
| SCHEMBL19030119 | 0.77 | MAPT (0.46) | IRAK4MAPTLMNAGAA | |
| SCHEMBL20594582 | 0.76 | MAPT (0.44) | IRAK4MAPTCYP3A4BLMPMP22 | |
| SCHEMBL19030476 | 0.76 | IRAK4 (0.49) | IRAK4MAPTCYP3A4BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094292-A | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-05-01 | — | — | CN | disclosed |