Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.48 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927566 | 0.89 | ROCK2 (0.54) | ROCK2ROCK1MYLK4 | |
| SCHEMBL23927565 | 0.89 | ROCK2 (0.54) | ROCK2ROCK1MYLK4 | |
| SCHEMBL28890004 | 0.87 | ROCK2 (0.36) | ROCK2ROCK1 | |
| SCHEMBL23927561 | 0.85 | ROCK2 (0.57) | ROCK2ROCK1MYLK4 | |
| SCHEMBL23927620 | 0.85 | ROCK2 (0.56) | ROCK2ROCK1MYLK4 | |
| SCHEMBL23927650 | 0.83 | ROCK2 (0.58) | ROCK2ROCK1MYLK4 | |
| SCHEMBL23927652 | 0.83 | ROCK2 (0.58) | ROCK2ROCK1MYLK4 | |
| SCHEMBL23963844 | 0.82 | ROCK2 (0.61) | ROCK2ROCK1 | |
| SCHEMBL23963655 | 0.82 | ROCK2 (0.52) | ROCK2ROCK1 | |
| SCHEMBL23927716 | 0.81 | ROCK2 (0.61) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217834-B | Nitroxide derivatives of ROCK kinase inhibitors | 维眸生物科技（上海）有限公司 | 2021-10-26 | — | — | CN | claimed |
| CN-111217834-B | Nitroxide derivatives of ROCK kinase inhibitors | 维眸生物科技（上海）有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-111217834-A | Nitroxide derivatives of ROCK kinase inhibitors | 维眸生物科技（上海）有限公司 | 2020-06-02 | — | — | CN | disclosed |