Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 1.00 |
| ▸ | NAMPT | P43490 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402820 | 0.85 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2 | |
| SCHEMBL7657154 | 0.83 | HDAC1 (0.71) | HDAC1NAMPTMEN1LMNAMAPT | |
| SCHEMBL28410650 | 0.83 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2NCOR2 | |
| SCHEMBL7657162 | 0.80 | MEN1 (0.74) | HDAC1MEN1LMNAMAPTPKM | |
| SCHEMBL28404719 | 0.80 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2NCOR2 | |
| SCHEMBL28409508 | 0.78 | HDAC1 (0.81) | HDAC1NAMPTHDAC3HDAC2NCOR2 | |
| SCHEMBL28402859 | 0.78 | HDAC1 (1.00) | HDAC1NAMPTMAPTHDAC3HDAC2 | |
| SCHEMBL28402288 | 0.77 | HDAC1 (1.00) | HDAC1NAMPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2413412 | 0.77 | HDAC1 (0.67) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL28405516 | 0.76 | HDAC1 (1.00) | HDAC1NAMPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106916101-B | NAMPT/HDAC double-target inhibitor and preparation method thereof | 聚缘（上海）生物科技有限公司 | 2020-05-01 | — | — | CN | claimed |
| CN-106916101-B | NAMPT/HDAC double-target inhibitor and preparation method thereof | 聚缘（上海）生物科技有限公司 | 2020-05-01 | — | — | CN | disclosed |