Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.81 |
| ▸ | NAMPT | P43490 | 2/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28404719 | 0.89 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL28402859 | 0.88 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL28410650 | 0.88 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL28402820 | 0.82 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL2414369 | 0.81 | HDAC1 (0.80) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL28402288 | 0.80 | HDAC1 (1.00) | HDAC1NAMPTHDAC2 | |
| SCHEMBL28408166 | 0.78 | HDAC1 (1.00) | HDAC1NAMPTHDAC3HDAC2NCOR2 | |
| SCHEMBL2415564 | 0.76 | HDAC1 (0.66) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL8614130 | 0.75 | MAOB (0.71) | HDAC1NAMPT | |
| SCHEMBL2410081 | 0.74 | HDAC1 (0.78) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106916101-B | NAMPT/HDAC double-target inhibitor and preparation method thereof | 聚缘（上海）生物科技有限公司 | 2020-05-01 | — | — | CN | claimed |
| CN-106916101-B | NAMPT/HDAC double-target inhibitor and preparation method thereof | 聚缘（上海）生物科技有限公司 | 2020-05-01 | — | — | CN | disclosed |