SCHEMBL28409504

SCHEMBL28409504

CC(=O)c1c(-c2ccccc2)cc(-c2ccccc2)cc1-c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.52
MAPT P10636 1/20 0.52
PTPN1 P18031 1/20 0.52
PTGS1 P23219 1/20 0.50
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
HK2 P52789 1/20 0.45
BACE1 P56817 2/20 0.44
TSHR P16473 1/20 0.43
HPRT1 P00492 1/20 0.42
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
IKBKB O14920 2/20 0.41
CHUK O15111 1/20 0.41
IKBKE Q14164 1/20 0.41
PKMYT1 Q99640 1/20 0.41
KDM4E B2RXH2 2/20 0.41
KMT2A Q03164 2/20 0.41
ADORA3 P0DMS8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459528 0.89 PTGS1 (0.49) SMN1; SMN2MAPTPTPN1PTGS1ALDH1A1
SCHEMBL10029662 0.83 PTPN1 (0.55) SMN1; SMN2MAPTPTPN1PTGS1ALDH1A1
SCHEMBL31457344 0.83 PTPN1 (0.60) PTPN1PTGS1ALDH1A1HPGDBACE1
SCHEMBL11530828 0.83 SMN1; SMN2 (0.50) SMN1; SMN2MAPTALDH1A1LMNAHPGD
SCHEMBL17459510 0.81 CYP1A2 (0.44) SMN1; SMN2MAPTPTPN1PTGS1ALDH1A1
SCHEMBL6846138 0.79 BCAT2 (0.53) MAPTPTPN1PTGS1BACE1TSHR
SCHEMBL2379485 0.79 SMN1; SMN2 (0.52) SMN1; SMN2MAPTPTGS1ALDH1A1LMNA
SCHEMBL17459516 0.79 PTPN1 (0.51) PTPN1PTGS1ALDH1A1HPGDHPRT1
SCHEMBL28405080 0.79 MAPT (0.56) SMN1; SMN2MAPTPTPN1PTGS1ALDH1A1
SCHEMBL1667186 0.79 SMN1; SMN2 (0.42) SMN1; SMN2MAPTPTPN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106999380-B Hair deforming agent 花王株式会社 2020-05-05 CN disclosed
CN-106999380-A Hair deforming agent 花王株式会社 2017-08-01 CN disclosed