Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.61 |
| ▸ | BCHE | P06276 | 6/20 | 0.59 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29550221 | 0.99 | ACHE (0.63) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL1114944 | 0.99 | ACHE (0.63) | ACHEBCHEFAAHABCC4CACNA1F | |
| Hydrochloric Acid SCHEMBL4833887 | 0.97 | ACHE (0.61) | ACHEBCHEFAAHABCC4CACNA1F | |
| Acetic Acid SCHEMBL29374009 | 0.93 | ACHE (0.60) | ACHEBCHEFAAHABCC4CACNA1F | |
| Acetic Acid SCHEMBL27493902 | 0.93 | ACHE (0.60) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL13317859 | 0.90 | ACHE (0.54) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL14156625 | 0.90 | ACHE (0.54) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4198622 | 0.86 | ACHE (0.56) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL14215561 | 0.85 | ACHE (0.80) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL5442562 | 0.84 | ACHE (0.61) | ACHEBCHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651234-B | Synthesis method of donepezil hydrochloride | 山东罗欣药业集团股份有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-109354580-B | Preparation method of donepezil hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-111100062-A | Synthesis method of donepezil hydrochloride | 山东罗欣药业集团恒欣药业有限公司 | 2020-05-05 | — | — | CN | disclosed |