Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409652 | 0.90 | NPY4R (0.41) | LARS1ITGB3ITGA2BTDP1POLB | |
| Arginine SCHEMBL16552839 | 0.86 | CASR (0.44) | OTCTDP1POLBKMT2ADDAH1 | |
| Arginine SCHEMBL16553173 | 0.86 | CASR (0.44) | OTCTDP1POLBKMT2ADDAH1 | |
| Arginine SCHEMBL28968791 | 0.86 | EPHX2 (0.42) | OTC | |
| Arginine SCHEMBL16879777 | 0.82 | KIF11 (0.47) | OTCTDP1NOS3NOS1NOS2 | |
| Arginine SCHEMBL28268971 | 0.82 | OTC (0.53) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL26914670 | 0.81 | KIF11 (0.46) | OTCTDP1POLBKMT2ADDAH1 | |
| Arginine SCHEMBL17874428 | 0.80 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL6468370 | 0.80 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL17874429 | 0.80 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269206-A | Synthetic method and application of arginine derivative Bz-Arg-AMC | 重庆医药高等专科学校 | 2020-06-12 | — | — | CN | disclosed |
| CN-111233973-A | Synthesis method and application of arginine derivative Pro-Phe-Arg-AMC | 重庆医药高等专科学校 | 2020-06-05 | — | — | CN | disclosed |
| CN-111196838-A | Synthesis method and application of arginine derivative Cbz-Phe-Arg-AMC | 重庆医药高等专科学校 | 2020-05-26 | — | — | CN | disclosed |