Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.73 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.62 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28408662 | 0.90 | HDAC6 (0.74) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2224178 | 0.88 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL28890895 | 0.87 | HDAC6 (0.60) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2223535 | 0.86 | HDAC6 (0.84) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL10050234 | 0.85 | HDAC6 (0.82) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| Ricolinostat SCHEMBL574580 | 0.84 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL10050271 | 0.83 | HDAC6 (0.81) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL6878041 | 0.83 | HDAC6 (0.79) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL28411809 | 0.83 | HDAC6 (0.56) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21707466 | 0.83 | HDAC6 (0.98) | HDAC6HDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110885316-B | Sulfhydryl compound as histone deacetylase inhibitor and application thereof | 上海中泽医药科技有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-110885316-B | Sulfhydryl compound as histone deacetylase inhibitor and application thereof | 上海中泽医药科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-110885316-A | Sulfhydryl compound as histone deacetylase inhibitor and application thereof | 上海中泽医药科技有限公司 | 2020-03-17 | — | — | CN | disclosed |