Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14432062 | 0.80 | PSEN1 (0.41) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL2301080 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL21335536 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL26607392 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL30325623 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL25201032 | 0.79 | MEN1 (0.39) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL4671635 | 0.78 | KMT2A (0.38) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL29895682 | 0.78 | KMT2A (0.41) | MEN1MAPK1KMT2AGAANFKB1 | |
| SCHEMBL17586286 | 0.78 | MEN1 (0.63) | MEN1MAPK1KMT2AEPHX2CACNA1H | |
| SCHEMBL21335537 | 0.77 | NAMPT (0.38) | MEN1MAPK1KMT2AGAANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269217-A | Pyrimidinamine compound, preparation method and application thereof | 苏州信诺维医药科技有限公司 | 2020-06-12 | — | — | CN | disclosed |