Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 1/20 | 0.45 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29793721 | 1.00 | KCNB1 (0.45) | KCNB1KCNB2TP53KDM4ETSHR | |
| SCHEMBL28406253 | 0.85 | KCNB1 (0.56) | KCNB1KCNB2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28410953 | 0.84 | KCNB1 (0.68) | KCNB1KCNB2KDM4EALDH1A1 | |
| SCHEMBL28406352 | 0.84 | MAPT (0.48) | KCNB1KCNB2TP53KDM4ETSHR | |
| SCHEMBL29793887 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28257362 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL29793613 | 0.80 | KCNB1 (0.51) | KCNB1KDM4EHSD17B10ALDH1A1PSMB5 | |
| SCHEMBL28409921 | 0.80 | KCNB1 (0.51) | KCNB1KDM4EHSD17B10ALDH1A1PSMB5 | |
| SCHEMBL29793727 | 0.78 | KCNB1 (0.55) | KCNB1KCNB2 | |
| SCHEMBL28257384 | 0.78 | KCNB1 (0.55) | KCNB1KCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |