Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.42 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.42 |
| ▸ | LCLAT1 | Q6UWP7 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411034 | 0.86 | LMNA (0.61) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL29793721 | 0.84 | KCNB1 (0.45) | ALDH1A1KCNB1KCNB2TP53KDM4E | |
| SCHEMBL28413504 | 0.84 | KCNB1 (0.45) | ALDH1A1KCNB1KCNB2TP53KDM4E | |
| SCHEMBL28257375 | 0.81 | LMNA (0.61) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28413200 | 0.81 | KCNB1 (0.48) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28410953 | 0.81 | KCNB1 (0.68) | MAPTMEN1KMT2AALDH1A1KCNB1 | |
| SCHEMBL28257377 | 0.80 | KCNB1 (0.52) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28406386 | 0.79 | ALDH1A1 (0.49) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28408082 | 0.75 | ALDH1A1 (0.46) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28890744 | 0.72 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |