Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817861 | 1.00 | TACR1 (0.42) | TACR1CHRM4MEN1LMNAHTT | |
| SCHEMBL2817089 | 0.93 | DPP4 (0.43) | CHRM4MC4RDPP4KDM1AMAOA | |
| SCHEMBL13841884 | 0.92 | DRD2 (0.44) | CHRM4MC4RDPP4DRD2DRD4 | |
| SCHEMBL2821338 | 0.92 | DRD2 (0.44) | CHRM4MC4RDPP4DRD2DRD4 | |
| SCHEMBL2821782 | 0.91 | DPP4 (0.45) | CHRM4MC4RDPP4KDM1ADRD2 | |
| SCHEMBL2817914 | 0.91 | DRD2 (0.47) | CHRM4LMNAMC4RDPP4KDM1A | |
| SCHEMBL2822155 | 0.90 | CHRM4 (0.44) | CHRM4MC4RDPP4DRD2DRD4 | |
| SCHEMBL2818985 | 0.88 | NPFFR1 (0.42) | CHRM4HTTMC4RDPP4DRD2 | |
| SCHEMBL2839427 | 0.88 | BCHE (0.46) | CHRM4MC4RDPP4DRD2DRD4 | |
| SCHEMBL2839423 | 0.88 | BCHE (0.46) | CHRM4MC4RDPP4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-B1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-27 | — | — | EP | disclosed |