Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138124 | 0.90 | SMN1; SMN2 (0.56) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22765331 | 0.88 | TMEM97 (0.57) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3678408 | 0.88 | TMEM97 (0.57) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28412948 | 0.87 | SMN1; SMN2 (0.53) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28412743 | 0.87 | SMN1; SMN2 (0.53) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30668752 | 0.87 | SMN1; SMN2 (0.53) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1930828 | 0.85 | SMN1; SMN2 (0.64) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5103812 | 0.84 | CHRM1 (0.61) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30773875 | 0.84 | SMN1; SMN2 (0.61) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14529819 | 0.84 | SMN1; SMN2 (0.61) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111278840-B | Pyrrolo [2,3-B ] pyridine compounds and their use for the treatment of cancer | 癌症研究科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | disclosed |
| CN-111278840-A | Pyrrolo [2, 3-B ] pyridine compounds and their use for treating cancer | 癌症研究科技有限公司 | 2020-06-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | TMEM97 4635/4885SIGMAR1 4644/4885SMN1; SMN2 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.