Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367281 | 0.85 | KLKB1 (0.40) | KLKB1RIPK1GABRA5P2RX7CYP2C9 | |
| SCHEMBL18367120 | 0.84 | TSHR (0.47) | MEN1NPC1RAB9AKMT2AKLKB1 | |
| SCHEMBL20156317 | 0.83 | KLKB1 (0.40) | MEN1NPC1RAB9AKMT2AKLKB1 | |
| SCHEMBL18367236 | 0.82 | ADORA2A (0.40) | KLKB1NOTUMRIPK1KDM4EL3MBTL1 | |
| SCHEMBL30092730 | 0.82 | NPSR1 (0.46) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18367122 | 0.82 | NPSR1 (0.46) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18366900 | 0.81 | NPC1 (0.63) | MEN1NPC1RAB9AKMT2ANOTUM | |
| SCHEMBL30587636 | 0.81 | RIPK1 (0.52) | MEN1NPC1RAB9AKMT2ARIPK1 | |
| SCHEMBL18366884 | 0.81 | RIPK1 (0.52) | MEN1NPC1RAB9AKMT2ARIPK1 | |
| SCHEMBL30587505 | 0.81 | NPC1 (0.63) | MEN1NPC1RAB9AKMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-112979660-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107849023-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111269221-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-06-12 | — | — | CN | disclosed |