Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24754644 | 0.76 | IDO1 (0.46) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL28827997 | 0.73 | IDO1 (0.44) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL1491212 | 0.73 | KDM4E (0.47) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL28859743 | 0.73 | IDO1 (0.46) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL29197967 | 0.73 | IDO1 (0.50) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL10338752 | 0.73 | KDM4E (0.57) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL8226202 | 0.72 | MAPT (0.43) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| Hydrochloric Acid SCHEMBL1491278 | 0.72 | KDM4E (0.46) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL2693278 | 0.69 | IDO1 (0.64) | IDO1MAPTALDH1A1L3MBTL1TDO2 | |
| SCHEMBL19000599 | 0.69 | IDO1 (0.51) | IDO1MAPTALDH1A1L3MBTL1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285872-B | Indole-2-ketone derivative and preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-111285872-A | Indole-2-ketone derivative and preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2020-06-16 | — | — | CN | disclosed |