Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | JAK3 | P52333 | 10/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12148936 | 0.86 | JAK3 (0.42) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL1376989 | 0.82 | JAK3 (0.57) | JAK1JAK2JAK3TSHRTYK2 | |
| SCHEMBL28407748 | 0.82 | JAK3 (0.57) | JAK1JAK2JAK3TSHRTYK2 | |
| SCHEMBL22428979 | 0.82 | JAK3 (0.57) | JAK1JAK2JAK3TSHRTYK2 | |
| SCHEMBL1374052 | 0.82 | JAK3 (0.57) | JAK1JAK2JAK3TSHRTYK2 | |
| SCHEMBL19757372 | 0.82 | GPR119 (0.47) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL2320091 | 0.81 | JAK2 (0.42) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL17285450 | 0.81 | JAK3 (0.60) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL12546233 | 0.79 | JAK3 (0.51) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL12566651 | 0.79 | JAK3 (0.51) | JAK1JAK2JAK3TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | claimed |
| CN-111588724-A | Use of pyrrolopyrimidine derivatives in the treatment of Janus kinase mediated diseases | 黄泳华 | 2020-08-28 | — | — | CN | claimed |
| CN-111202736-A | Compositions containing a mixture of pyrrolopyrimidine derivatives and uses thereof | 黄泳华 | 2020-05-29 | — | — | CN | claimed |
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | disclosed |
| CN-111588724-A | Use of pyrrolopyrimidine derivatives in the treatment of Janus kinase mediated diseases | 黄泳华 | 2020-08-28 | — | — | CN | disclosed |
| CN-111202736-A | Compositions containing a mixture of pyrrolopyrimidine derivatives and uses thereof | 黄泳华 | 2020-05-29 | — | — | CN | disclosed |