SCHEMBL28419429

SCHEMBL28419429

CC(C)CC(NC(=O)OC(C)(C)C)C(=S)OCCCBr

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSK P43235 3/20 0.48
CTSL P07711 2/20 0.48
CTSS P25774 2/20 0.48
CTSB P07858 1/20 0.48
CAPN1 P07384 1/20 0.46
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
CA7 P43166 1/20 0.43
AAK1 Q2M2I8 1/20 0.42
GAA P10253 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CA12 O43570 2/20 0.39
CA9 Q16790 2/20 0.39
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTT P42858 1/20 0.36
MAP1LC3B Q9GZQ8 1/20 0.36
MAP1LC3A Q9H492 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27808939 0.88 CTSK (0.51) CTSKCTSLCTSSCTSBCAPN1
SCHEMBL27808938 0.88 CTSK (0.51) CTSKCTSLCTSSCTSBCAPN1
SCHEMBL28414218 0.84 CA1 (0.44) CTSKCTSLCTSSCTSBCA1
SCHEMBL28421451 0.82 CTSK (0.46) CTSKCTSLCTSSCTSBCA1
SCHEMBL28423245 0.81 CTSK (0.49) CTSKCTSSCA1CA2CA7
SCHEMBL27808914 0.79 CA1 (0.47) CTSKCTSLCTSSCTSBCA1
SCHEMBL27808912 0.79 CA1 (0.47) CTSKCTSLCTSSCTSBCA1
SCHEMBL13519734 0.76 CTSK (0.52) CTSKCTSLCTSSCTSBCAPN1
SCHEMBL21675512 0.76 CTSK (0.61) CTSKCTSLCTSSCTSBCAPN1
SCHEMBL1041131 0.75 CTSK (0.57) CTSKCTSLCTSSCTSBCAPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106117295-B Adefovir monothiol-amino acid ester mono-cholate derivative and preparation method thereof 贵州医科大学 2020-05-22 CN disclosed