Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20346252 | 0.80 | AXL (0.36) | CHRM1DRD2DRD4DRD3PDE4A | |
| SCHEMBL19459108 | 0.77 | MAP4K4 (0.33) | CHRM1DRD2DRD4DRD3PDE4A | |
| SCHEMBL18390622 | 0.74 | ESR2 (0.34) | CHRM1DRD2DRD4DRD3PDE4A | |
| SCHEMBL1992738 | 0.74 | SCN5A (0.38) | CA1CA2CHRM1DRD2DRD4 | |
| SCHEMBL2355368 | 0.73 | BRD9 (0.37) | — | |
| SCHEMBL20412783 | 0.72 | JAK2 (0.31) | CA1CA2PDE4APDE4CPDE4D | |
| SCHEMBL19482428 | 0.71 | DRD2 (0.34) | CHRM1DRD2DRD4DRD3HSD11B1 | |
| SCHEMBL27171951 | 0.70 | MAP4K4 (0.38) | CHRM1DRD2DRD4DRD3ADORA2A | |
| SCHEMBL22660675 | 0.70 | RET (0.35) | — | |
| SCHEMBL3228819 | 0.70 | AXL (0.39) | DRD2DRD4DRD3DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891149-B1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2026-01-28 | — | — | EP | disclosed |
| CN-111285873-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-111285873-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |