Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640877 | 0.87 | MIF (0.40) | HTTCYP1A2CYP2C19 | |
| SCHEMBL20640968 | 0.86 | TDP1 (0.31) | — | |
| SCHEMBL28418753 | 0.85 | POLB (0.35) | HPGDHTTPOLBAPAF1GRK2 | |
| SCHEMBL20640508 | 0.74 | MLYCD (0.32) | CYP1A2CYP2C19 | |
| SCHEMBL3302336 | 0.62 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL4995291 | 0.62 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL25061491 | 0.61 | MIF (0.35) | HTTPOLBCYP1A2CYP2C19 | |
| SCHEMBL10759359 | 0.61 | — | — | |
| SCHEMBL5793246 | 0.61 | — | — | |
| SCHEMBL9548274 | 0.61 | POLB (0.46) | HPGDHTTPOLBAPAF1GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914271-A | Bicyclic ketone compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-03-24 | — | — | CN | disclosed |