SCHEMBL28422697

SCHEMBL28422697

COc1ccc(-n2c3cc(Br)ccc3c3ccc(Br)cc32)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.44
LMNA P02545 2/20 0.44
CLK1 P49759 1/20 0.43
GSK3B P49841 1/20 0.43
DYRK1A Q13627 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
DYRK1B Q9Y463 1/20 0.43
SMN1; SMN2 Q16637 4/20 0.42
HPGD P15428 3/20 0.42
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
RAB9A P51151 2/20 0.42
NPC1 O15118 2/20 0.42
NPM1 P06748 1/20 0.42
ALK Q9UM73 1/20 0.42
USP2 O75604 1/20 0.42
MAPK1 P28482 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28597230 0.88 ALDH1A1 (0.39) MAPTLMNASMN1; SMN2HPGDALDH1A1
SCHEMBL10134266 0.87 KDM4E (0.46) MAPTLMNAHPGDALDH1A1KMT2A
SCHEMBL669186 0.86 MAPT (0.45) MAPTLMNASMN1; SMN2HPGDALDH1A1
SCHEMBL30952420 0.86 MAPT (0.45) MAPTLMNASMN1; SMN2HPGDALDH1A1
SCHEMBL4254063 0.85 MAPT (0.49) MAPTLMNACLK1GSK3BDYRK1A
SCHEMBL38654175 0.84 GSK3B (0.36) MAPTLMNACLK1GSK3BDYRK1A
SCHEMBL38654551 0.84 GSK3B (0.36) MAPTLMNACLK1GSK3BDYRK1A
SCHEMBL28317572 0.83 TSHR (0.38) MAPTGSK3BHPGDALDH1A1MAPK1
SCHEMBL30018831 0.83 MAPT (0.53) MAPTLMNASMN1; SMN2HPGDALDH1A1
SCHEMBL5999407 0.83 MAPT (0.53) MAPTLMNASMN1; SMN2HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114316219-B Polymer with electrochromic and thermochromic properties as well as preparation method and application thereof 北京大学深圳研究生院 2023-11-28 CN disclosed
CN-114316219-A Polymer with electrochromic and thermochromic performances as well as preparation method and application thereof 北京大学深圳研究生院 2022-04-12 CN disclosed
CN-106977491-B Spiro [ fluorene-9, 9-xanthene ] hole transport material and application thereof 孙立成 2020-06-19 CN disclosed