Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL4155411 | 0.95 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Butane SCHEMBL22619597 | 0.89 | CXCR4 (0.64) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Propane SCHEMBL3971658 | 0.86 | HIF1A (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27557138 | 0.86 | — | — | |
| Pyrrolidine SCHEMBL631271 | 0.84 | — | — | |
| Piperazine SCHEMBL27708668 | 0.84 | TSHR (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27853221 | 0.82 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Azetidine SCHEMBL28080407 | 0.82 | — | — | |
| Nonane SCHEMBL10873465 | 0.81 | TSHR (0.57) | HIF1AMAPTPDE4AKDRALDH1A1 | |
| Piperazine SCHEMBL3344476 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120136781-A | ROR 1-targeted inhibitor and synthesis method and application thereof | 北京大学 | 2025-06-13 | — | — | CN | claimed |
| CN-118914314-B | Quantitative determination method for metastable iron oxide vacancy defect concentration | 华中农业大学 | 2025-05-06 | — | — | CN | claimed |
| CN-119736013-A | Partially crystallized outer coating for marine optical fiber and preparation method thereof | 长飞光纤光缆股份有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119121438-A | Anti-gelling spinning method for liquid crystal elastomer fiber | 华南理工大学 | 2024-12-13 | — | — | CN | claimed |
| CN-118914314-A | Quantitative determination method for metastable iron oxide vacancy defect concentration | 华中农业大学 | 2024-11-08 | — | — | CN | claimed |
| CN-115044206-B | Low-loss preparation method of polyimide foam filled honeycomb | 江苏中科聚合新材料产业技术研究院有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-112771056-B | Metal organic framework phase and crystallite shape control | 加利福尼亚大学董事会 | 2024-02-23 | — | — | CN | claimed |
| CN-113527681-B | Organic silicon doped polyimide soft foam material, and preparation method and application thereof | 常州福隆科技新材料有限公司 | 2023-08-22 | — | — | CN | claimed |
| CN-112979905-B | Block polyurethane polymer, polymer modified bentonite admixture thereof, and preparation and application thereof | 江苏苏博特新材料股份有限公司 | 2023-03-14 | — | — | CN | claimed |
| CN-115011222-A | Single-component polyurea matte seam beautifying agent | 安徽硕阳新材料科技有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-103541281-A | Railroad sleeper with multiplayer structure | ZHAO WEI | 2014-01-29 | — | — | CN | claimed |
| CN-103012712-A | Method for preparing organic and inorganic hybridization modified polyurethane chemical grouting material | HEBEI TONGCHENG TECHNOLOGY CO LTD | 2013-04-03 | — | — | CN | claimed |
| CN-101588880-B | Use of amine blends for foundry cores and foundry metals | ARKEMA FRANCE | 2012-03-07 | — | — | CN | claimed |
| CN-101323701-B | Long glass fiber reinforced hard polyurethane synthetic material sleeper and method for preparing the same | UNIV NANJING FORESTRY | 2010-06-23 | — | — | CN | claimed |
| US-20100126690-A1 | USE OF AMINE BLENDS FOR FOUNDRY SHAPED CORES AND CASTING METALS | ARKEMA FRANCE (FR) | 2010-05-27 | — | — | US | claimed |
| CN-101588880-A | Use of amine blends for foundry cores and foundry metals | ARKEMA FRANCE (FR) | 2009-11-25 | — | — | CN | claimed |
| EP-2106310-A1 | USE OF AMINE BLENDS FOR FOUNDRY SHAPED CORES AND CASTING METALS | ARKEMA FRANCE (FR) | 2009-10-07 | — | — | EP | claimed |
| CN-100530545-C | Method for forming organic light-emitting layer | MECHARONICS CO LTD (KR) | 2009-08-19 | — | — | CN | claimed |
| CN-101323701-A | Long glass fiber reinforced hard polyurethane synthetic material sleeper and method for preparing the same | UNIV NANJING FORESTRY (CN) | 2008-12-17 | — | — | CN | claimed |
| WO-2008090161-A1 | USE OF AMINE BLENDS FOR FOUNDRY SHAPED CORES AND CASTING METALS | ARKEMA FRANCE (FR) | 2008-07-31 | — | — | WO | claimed |