Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 4/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.31 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propanol SCHEMBL27831630 | 0.87 | — | — | |
| Pyrrolidine SCHEMBL17377306 | 0.87 | — | — | |
| Azetidine SCHEMBL9683634 | 0.86 | — | — | |
| Piperazine SCHEMBL1485419 | 0.85 | — | — | |
| Piperazine SCHEMBL9506704 | 0.85 | ALDH1A1 (0.50) | HIF1AMAPTPDE4AKDRALDH1A1 | |
| Piperazine SCHEMBL27660902 | 0.84 | ALDH1A1 (0.65) | HIF1AMAPTPDE4AKDRALDH1A1 | |
| Piperidine SCHEMBL2914572 | 0.84 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CXCR4LMNATSHR | |
| Piperazine SCHEMBL28751263 | 0.82 | ALDH1A1 (0.61) | HIF1AMAPTPDE4AKDRALDH1A1 | |
| Piperazine SCHEMBL22092466 | 0.81 | ALDH1A1 (0.46) | HIF1AMAPTPDE4AKDRALDH1A1 | |
| Piperazine SCHEMBL29044668 | 0.81 | ALDH1A1 (0.46) | HIF1AMAPTPDE4AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104046246-B | The chemical-mechanical planarization of tungsten-containing substrate | 气体产品与化学公司 | 2016-06-15 | — | — | CN | claimed |
| CN-101193867-A | N-substituted benzimidazolyl c-Kit inhibitors and combinatorial benzimidazole libraries | OSI PHARM INC (US) | 2008-06-04 | — | — | CN | claimed |
| CN-87104499-A | Novel alginic acid esters | — | 1988-04-06 | — | — | CN | claimed |
| US-4546177-A | 1-(6-Hydroxy-4- or -7-methoxy-5-Benzofuranyl)-4-substituted-1,3-butanediones | THE UPJOHN COMPANY (US) | 1985-10-08 | — | — | US | claimed |
| CN-119118957-A | Hyperbranched polymer pentaerythritol tetra (2-piperazinyl propionate), preparation method thereof and application of hyperbranched polymer pentaerythritol tetra (2-piperazinyl propionate) in capturing carbon dioxide | 上海禧真环境科技有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-119080718-A | Trimethylolpropane tris (2-piperazinyl propionate) and application thereof as carbon dioxide absorbent | 上海禧真环境科技有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-118359612-A | Compounds and pharmaceutical compositions for the treatment of diseases | 加拉帕戈斯股份有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-112292129-B | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases | 加拉帕戈斯股份有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-110198932-A | Alkanolamine, anti-friction agent and lubricant oil composite | 东曹株式会社 | 2019-09-03 | — | — | CN | disclosed |
| CN-107708739-A | Ionizable compound, composition and their purposes | 日东电工株式会社 | 2018-02-16 | — | — | CN | disclosed |
| CN-105111142-B | Hydroxypiperaquin and its method for production of phosphate salt | 苏州摩尔医药有限公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-106046370-A | Oxazoline POZ compound, method for synthesizing the same, and target molecule-POZ conjugate | 塞瑞纳治疗公司 | 2016-10-26 | — | — | CN | disclosed |
| WO-1992000290-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |
| WO-1991019707-A2 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1991-12-26 | — | — | WO | disclosed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| US-5055517-A | Aqueous gel of substituted acrylamide crosslinked with dimethacrylate | AT BIOCHEM (US) | 1991-10-08 | — | — | US | disclosed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | disclosed |
| EP-0339678-A2 | Electrophoretic media | AT BIOCHEM (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4837324-A | Process for the reaction of piperazine, and derivatives thereof, with glyoxal, and derivatives thereof | THE DOW CHEMICAL COMPANY (US) | 1989-06-06 | — | — | US | disclosed |
| US-4761476-A | Compounds formed by the reaction of piperazine, and derivatives thereof, with glyoxal, and derivatives thereof | THE DOW CHEMICAL COMPANY (US) | 1988-08-02 | — | — | US | disclosed |