Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30646060 | 1.00 | KDR (0.45) | KDRPDGFRAEGFRFGFR1FLT1 | |
| SCHEMBL30646047 | 0.86 | PDGFRA (0.42) | KDRPDGFRAEGFRKITACHE | |
| SCHEMBL29111064 | 0.86 | PDGFRA (0.42) | KDRPDGFRAEGFRKITACHE | |
| SCHEMBL29111046 | 0.82 | PDGFRA (0.43) | KDRPDGFRAEGFRKITACHE | |
| SCHEMBL13998242 | 0.79 | EGFR (0.42) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5015530 | 0.79 | EGFR (0.42) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL30645978 | 0.79 | PDGFRA (0.48) | KDRPDGFRAFLT4PDGFRBABCG2 | |
| SCHEMBL29111055 | 0.79 | PDGFRA (0.48) | KDRPDGFRAFLT4PDGFRBABCG2 | |
| Hydrochloric Acid SCHEMBL30891771 | 0.77 | KDR (0.51) | KDRPDGFRAEGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL26098361 | 0.77 | KDR (0.51) | KDRPDGFRAEGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253385-B | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2023-11-24 | — | — | CN | disclosed |
| CN-111253385-A | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2020-06-09 | — | — | CN | disclosed |