Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 10/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28427873 | 1.00 | PTGER4 (0.52) | PTGER4PTGER3PTGER2KCNH2PTGS1 | |
| SCHEMBL16401236 | 0.84 | PTGER4 (0.41) | PTGER4PTGER3PTGER2KCNH2MEN1 | |
| SCHEMBL16058266 | 0.81 | PTGER4 (0.64) | PTGER4PTGER3PTGER2KCNH2PTGS1 | |
| SCHEMBL28436522 | 0.81 | PTGER4 (0.64) | PTGER4PTGER3PTGER2KCNH2PTGS1 | |
| SCHEMBL21658923 | 0.73 | PTGER4 (0.48) | PTGER4PTGER3PTGER2KCNH2 | |
| SCHEMBL11624805 | 0.72 | PTGER4 (0.59) | PTGER4PTGER3PTGER2 | |
| SCHEMBL21658922 | 0.72 | PTGER2 (0.71) | PTGER4PTGER3PTGER2KCNH2 | |
| SCHEMBL18943090 | 0.68 | PTGS1 (0.42) | PTGER4PTGER3PTGER2KCNH2PTGS1 | |
| SCHEMBL18942713 | 0.68 | PTGER4 (0.43) | PTGER4PTGER3PTGER2KCNH2MEN1 | |
| SCHEMBL11399389 | 0.67 | PTGS1 (0.47) | PTGER4PTGER3PTGER2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107802623-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-106748951-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2020-07-24 | — | — | CN | disclosed |