Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19513822 | 0.69 | TSHR (0.47) | PTGS1PTGS2MEN1GAAKMT2A | |
| SCHEMBL19513862 | 0.69 | TSHR (0.47) | PTGS1PTGS2MEN1GAAKMT2A | |
| SCHEMBL9151143 | 0.69 | TSHR (0.47) | PTGS1PTGS2MEN1GAAKMT2A | |
| SCHEMBL7416853 | 0.69 | TSHR (0.47) | PTGS1PTGS2MEN1GAAKMT2A | |
| SCHEMBL27763458 | 0.68 | NAAA (0.46) | PTGS1PTGS2KDM4EALDH1A1HPGD | |
| SCHEMBL2944990 | 0.67 | TSHR (0.49) | PTGS1PTGS2MEN1KMT2ATSHR | |
| SCHEMBL8381328 | 0.66 | CYP1A2 (0.65) | PTGS1PTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL25465029 | 0.64 | PTGS1 (0.57) | PTGS1PTGS2ALDH1A1MEN1GAA | |
| SCHEMBL5697933 | 0.64 | PTGS1 (0.61) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL27248010 | 0.64 | PTGS1 (0.61) | PTGS1PTGS2ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176162-A1 | DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS | Cayman Chemical Company, Incorporated (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-3175852-A1 | DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS | Cayman Chemical Company, Incorporated (US) | 2017-06-07 | — | — | EP | disclosed |