Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.72 |
| ▸ | FLT3 | P36888 | 12/20 | 0.72 |
| ▸ | KIT | P10721 | 8/20 | 0.72 |
| ▸ | CSF1R | P07333 | 5/20 | 0.72 |
| ▸ | FLT1 | P17948 | 5/20 | 0.72 |
| ▸ | FLT4 | P35916 | 3/20 | 0.72 |
| ▸ | LCK | P06239 | 2/20 | 0.72 |
| ▸ | RET | P07949 | 3/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21668695 | 0.93 | KDR (0.64) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21386473 | 0.93 | KDR (0.64) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21668595 | 0.88 | KDR (0.58) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21668601 | 0.87 | KDR (0.61) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21386467 | 0.87 | KDR (0.61) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL423660 | 0.87 | KDR (0.81) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21668631 | 0.86 | KDR (0.72) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL24799604 | 0.85 | KDR (0.54) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL24486690 | 0.84 | KDR (0.56) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL21668598 | 0.84 | KDR (0.56) | KDRFLT3KITCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109400597-B | VEGFR-2 inhibitor ABT-869-based protein degradation targeting chimera and preparation method and application thereof | 西安交通大学 | 2020-07-28 | — | — | CN | claimed |
| CN-109400597-B | VEGFR-2 inhibitor ABT-869-based protein degradation targeting chimera and preparation method and application thereof | 西安交通大学 | 2020-07-28 | — | — | CN | disclosed |