Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 6/20 | 0.56 |
| ▸ | PAK4 | O96013 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353135 | 0.77 | MEN1 (0.47) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL588674 | 0.77 | PAK4 (0.62) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL219046 | 0.74 | PAK4 (0.59) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL3993234 | 0.74 | PAK4 (0.49) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL22600946 | 0.74 | PAK4 (0.59) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL10294569 | 0.73 | PAK4 (0.49) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL220647 | 0.73 | PAK4 (0.57) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL218642 | 0.72 | MEN1 (0.62) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL218565 | 0.72 | PAK4 (0.60) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL3939475 | 0.72 | PAK4 (0.56) | PLK4PAK4MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423416-A | Inhibitors of RET | 蓝图药品公司 | 2020-07-17 | — | — | CN | disclosed |
| CN-108473468-B | Inhibitors of RET | 蓝图药品公司 | 2020-06-16 | — | — | CN | disclosed |