Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25088955 | 0.98 | TOP2A (0.30) | — | |
| SCHEMBL761343 | 0.82 | MAPT (0.33) | — | |
| SCHEMBL1386473 | 0.79 | — | — | |
| SCHEMBL8141548 | 0.78 | CHRM5 (0.30) | — | |
| SCHEMBL25959958 | 0.78 | — | — | |
| SCHEMBL8486661 | 0.76 | — | — | |
| SCHEMBL28429227 | 0.76 | — | — | |
| SCHEMBL8486668 | 0.76 | — | — | |
| SCHEMBL28429854 | 0.76 | MDM4 (0.31) | — | |
| SCHEMBL22122291 | 0.75 | RAB9A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098886-B | Prazinone-containing quinazolinone PARP-1/2 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-07-14 | — | — | CN | disclosed |