Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 11/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28434572 | 0.86 | KDR (0.71) | SRCRETPDGFRBPDGFRAFGFR1 | |
| SCHEMBL22505737 | 0.82 | KDR (0.54) | SRCCSF1RRETPDGFRBPDGFRA | |
| SCHEMBL22505593 | 0.80 | EGFR (0.57) | SRCCSF1RRETPDGFRBPDGFRA | |
| SCHEMBL31218187 | 0.79 | KDR (0.56) | CSF1RRETPDGFRBPDGFRAFGFR1 | |
| SCHEMBL1323767 | 0.79 | KDR (0.56) | CSF1RRETPDGFRBPDGFRAFGFR1 | |
| SCHEMBL22535136 | 0.78 | KDR (0.52) | SRCCSF1RRETPDGFRBPDGFRA | |
| SCHEMBL22535121 | 0.77 | PDGFRA (0.51) | SRCCSF1RRETPDGFRBPDGFRA | |
| SCHEMBL22505696 | 0.77 | FLT3 (0.56) | — | |
| SCHEMBL22505754 | 0.77 | KDR (0.46) | SRCCSF1RRETPDGFRBPDGFRA | |
| SCHEMBL28300775 | 0.77 | RIPK2 (0.59) | SRCRETKDRAURKBRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111298127-A | Composition comprising histamine release-promoting substance and inhibitory compound, and oral solid preparation containing the same | 黄泳华 | 2020-06-19 | — | — | CN | claimed |
| CN-111349045-A | Synthetic method of lenvatinib and novel intermediate | 江苏万邦生化医药集团有限责任公司 | 2020-06-30 | — | — | CN | disclosed |
| CN-111298127-A | Composition comprising histamine release-promoting substance and inhibitory compound, and oral solid preparation containing the same | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |